PRODUCT DESCRIPTION:

TESTROGAIN® is a complete scientific formula that supports relative testosterone levels and may help activate anabolic processes. It contains a natural mixture of testosterone and luteinizing hormone (LH) boosters combined with aromatase (antiestrogen) and dihydrotestosterone (DHT) inhibitors.

• Increase Testosterone levels
• Increase Stamina
• Muscle repair, rebuild and growth
• Increase energy
• Decrease body fat
• Increase muscle mass
• Increase strength
• Increase virility

What is testosterone?

Testosterone is the primary sex hormone produced in men's bodies. It helps maintain sex drive and the production of sperm cells. Mood is also affected by testosterone, and low levels of the hormone can cause severe and prolonged depression as well as fatigue. Testosterone is produced in the testes and the outer part of the adrenal glands called the adrenal cortex.

How does aging affect the body's ability to make testosterone?

Not only does the amount of testosterone produced decline with age, the morning spike of testosterone seen in young men is blunted in older men. The pituitary glands of older men also may produce less luteinizing hormone (LH), which decreases testosterone production. Testosterone in aging men is more likely to bind to sex hormone binding globulin (SHBG), which reduces the amount of freely circulating testosterone that is available to the body.

Can low testosterone levels cause other problems?

Studies have shown that men with low testosterone can become frail, lose muscle mass and suffer bone fractures due to osteoporosis. Researchers also have shown that men who are testosterone-deficient may be more likely to experience depression and reduced quality-of-life than men who produce adequate amounts of the hormone.

How does ageing affect the body's ability to make testosterone?

Not only does the amount of testosterone produced decline with age, the morning spike of testosterone seen in young men is blunted in older men. The pituitary glands of older men also may produce less luteinizing hormone (LH), which decreases testosterone production. Testosterone in aging men is more likely to bind to sex hormone binding globulin (SHBG), which reduces the amount of freely circulating testosterone that is available to the body.

Why would a doctor suspect that someone has a low level of testosterone?

Symptoms related to low testosterone include: decreased sex drive, erectile dysfunction (ED), lowered sperm count, increased breast size (a condition called gynecomastia), hot flashes, increased irritability, trouble concentrating and depression. Men who have a severe and prolonged reduction of testosterone also may experience loss of body hair, reduced muscle mass and bone fractures due to osteoporosis. Certain medical conditions also can cause the condition.

Testosterone Boosters and Testosterone Support:

1) ZMA – 100mg

ZMA is perhaps the best testosterone boosters currently available. ZMA is a scientifically designed mineral-support formula that can dramatically increase natural levels of anabolic hormones. In fact, if taken as recommended, ZMA can increase free testosterone by 30% while boosting IGF-1 levels significantly.What is ZMA and where does it come from? ZMA is a scientifically designed anabolic mineral formula. It contains Zinc Monomethionine Aspartate plus Magnesium Aspartate and vitamin B-6, and is an all-natural product that has been clinically proven to significantly increase anabolic hormone levels. What does it do and what scientific studies give evidence to support this?

There is a large body of scientific evidence supportive of ZMA. Zinc and Magnesium are commonly depleted from your body. Studies have shown that supplementing with 30mg of Zinc and 450mg of Magnesium per day can elevate testosterone levels up to 30%! In a recent study the ZMA group had 30% increases in free and total testosterone levels compared to 10 percent decreases in the placebo group.

2) Dehydroepiandrosterone (DHEA) -- 50 mg pharmaceutical grade.

By now you know that DHEA is a natural hormone produced mainly by the cortex (cap) of the adrenal glands (the glands that sit on top of your kidneys). You also may know that it's been implicated in physique development because it acts as an intermediate compound in the production of testosterone, the main anabolic hormone for both men and women.

DHEA is released when the adrenal cortex gets "told" to secrete it by a chemical messenger called adrenocorticotropic hormone (ACTH). ACTH, in turn, is released by the pituitary gland of the brain. Remember this. The fact that the brain initiated the process which results in DHEA secretion is important. As you might expect, DHEA secretion is in synch with testosterone secretion. That is, you start secreting DHEA when you're about seven years old, it peaks in your mid-20s, and then declines steadily with age. This fact has many sports scientists and athletes speculating that DHEA supplementation might keep endogenous testosterone levels high, not only reducing the lean body mass degeneration associated with aging, but also optimizing an athlete's anabolic state. What would result, then, is a leaner, more muscular person.

And there's even some good research behind it. Early studies by Yen et al. clearly demonstrated that DHEA could reduce body fat in genetically obese mice. And since then, research has continued to mount by many investigative teams. In rats, mice and rabbits, the effect of DHEA supplementation is consistent--muscle tissue increases and fat decreases.

Until very recently, however, there were fairly equivocal effects in humans. And, there was concern that the dosages you needed to get an effect in humans would also produce a very androgenic effect. (Not that some companies wouldn't pump you with high dosages anyway, regardless of the androgenic effects--they would.) All that's changed with new research.

Interestingly, we're finding that it's the lower dosages that are producing positive changes, while the higher dosages either do nothing or produce too many side effects (such as insulin resistance and increased serum cholesterol). Physicians believe that only in cases where DHEA is being used to reduce side effects of other medications should DHEA in higher dosages be considered.

A very recent human study found that single doses of 50 mg DHEA increased serum testosterone levels in men to the levels of younger men (the exact same amount of DHEA found in Newton-Everett Biotech®'s new TESTROGAIN®).

In another recent study, DHEA was shown to have a protective effect against cell damage in animals. In fact, the authors of this study note that "DHEA itself could act as a direct antioxidant." This may account for a January, 1998, report in The Journal of Trauma, showing DHEA preserved blood vessel function when blood flow was interrupted to tissues. And all this supports the various reports of DHEA acting in chemopreventive and cardioprotective roles. When you coupled this with the other documented health benefits of DHEA (reduction in the risk of heart disease, diabetes and hypertension; alleviation of symptoms of lupus), things get interesting.

3) Zinc (as zinc picolinate)--50 mg

In the past few years, zinc has resurfaced as a very important nutrient in growth and healing. And, to scientists, the results of recent studies showing a relation between zinc and testosterone probably come as no great surprise. After all, the mineral zinc has been implicated in growth processes since the early part of this century. Only recently has it gotten the attention it's deserved. Although scientists have known of the association between zinc status and testosterone levels, this relationship has always been noted in patients with certain diseases. However, two recent studies have shed new light on zinc supplements as a way to increase plasma testosterone and sperm count in infertile, but otherwise healthy men.

The first study was a classic in nutrition. Researchers actually produced zinc depletion in young men by feeding them controlled diets in a metabolic ward. Within just five weeks, serum testosterone concentrations and seminal volumes plummeted when the subjects ingested a very low zinc diet.

Your testosterone level, and with it your ability to add muscular size, can decrease rapidly and drastically when any of the following is true: You're eating a diet low in zinc (common for many bodybuilders); you're exercising regularly and vigorously; you're female and taking birth control pills.

In the second study, investigators charted the serum zinc and plasma testosterone concentrations of 123 normal pre-adolescent and adolescent boys, comparing these variables to stages of the subjects' sexual development. The researchers found a positive correlation between serum zinc, plasma testosterone and sexual maturation.

When serum zinc rose, plasma testosterone and sexual maturation increased also, illustrating once again the relationship between zinc status and the potential for muscular growth. Moreover, other studies have confirmed the relation between zinc levels and testosterone. For example, not only did Hartoma find a positive correlation (when one increased, the other went up also) between serum zinc and serum testosterone, but other scientists have found this same correlation between zinc and androgens in the testes.There are dangers associated with larger dosages of zinc. Toxic reactions can occur with 500-mg doses (33 times the RDA), and risks include increased chance of heart disease due to elevated cholesterol. Excess zinc interacts with other minerals, such as copper and iron. In fact, zinc supplementation has produced iron-deficiency anemia in animals.

So what's the right dosage? Our research shows us that 50 mg is what you need; enough to stimulate positive effects without getting near toxicity levels.

Natural Luteinizing Hormone (LH) Boosters

4) Acetyl-L-Carnitine--500 mg

Acetyl-L-Carnitine (ALC) is a relatively new substance to hit the lab scales. You know all about carnitine, right? It's the substance that's synthesized from lysine and methionine, and shuttles fats into the mitochondria of cells to be burned.

Well, about 10% of the total carnitine in the body is in this acetylated ester form called ALC. You can get ALC in your diet, but not usually in large amounts. ALC has been shown to lessen one's responses to stress, especially physical stress. It appears to do this both directly and indirectly by affecting the endocrine (hormonal) system.

5) Tribulus Terrestris Extract--150 mg

Tribulus terrestris is an herbal extract that has only recently been available.

Natural Aromatase Inhibitors (Anti-Estrogen) Aromatase is an enzyme that converts androstenedione to oestrone (which leads to an increase in the amount of circulating estrogen). Of course, this is not good for anyone wanting to maximize muscle tissue and minimize fat deposition. Some chemicals attempt to get in the way of aromatase, blocking this conversion. We've got the perfect dosage of the most effective anti-estrogen compounds:

6) Purified Soy Isoflavone Concentrate--200 mg (40% isoflavones)

By far, the most efficacious of the aromatase inhibitors are the soy isoflavones, a type of bioflavonoid. For decades, researchers have noted the role of soy isoflavones in the protection from breast cancer and other cancers. What does this have to do with anti-estrogen activity? You see, a lower risk of breast cancer and other cancers related to estrogen is directly related to a diminishe activation of estrogen receptors. The more activation, the greater the risk.

In fact, researchers began to notice the importance of soy isoflavones in the protective effect of lowered estrogen levels when finding that Asian populations have a lower frequency of breast cancer, yet consume a diet very high in soy isoflavones. Where the isoflavones come from is very important. There's something very distinctive about soy isoflavones. They appear to block the conversion of androstenedione to oestrone more effectively than any other substance; it's like a natural Nolvadex.

Recently, researchers at Emory University in Atlanta, GA, presented data showing genistein (a soy isoflavone) inhibited prostate cancer cell growth. Other research from Australia found that 40 mg per day isoflavones significantly increased HDL cholesterol.

Even the editors of HealthNews, from the publishers of The New England Journal of Medicine, when citing the exceptional health of Japanese women ingesting high amounts of isoflavones, write "Your goal should be to work up to 25 to 45 milligrams of isoflavones a day--the amount consumed by the average Japanese woman." TESTROGAIN® has 80mg.

Natural Dihydrotestosterone (DHT) Inhibitors:

As you know, the testes secrete several male sex hormones, which are collectively called androgens--testosterone, dihydrotestosterone, and androstenedione. When secreted, testosterone dwarfs the other two in concentration, so most people just refer to testosterone when discussing androgenic and anabolic effects of these hormones. Following secretion by the testes, most of the testosterone becomes loosely bound with either plasma albumin or a beta-globulin called gonadal steroid-binding globulin and circulates in the blood for about 20 minutes. By that time, it either adheres to tissues or becomes degraded into inactive products that are subsequently excreted. Much, if not most, of the testosterone that adheres to tissues is converted within the cells to dihydrotestosterone (a smaller amount goes to 5-alpha-androstanediol), commonly referred to as DHT. This is why we say that testosterone is converted to DHT at target tissues. Every target tissue, from the prostate to muscle cells, sees this conversion to some degree.

The rationale behind DHT inhibitors is that (a) if the conversion of testosterone to dihydrotestosterone is blocked, testosterone will remain in the bloodstream longer to positively affect and activate anabolic processes within muscle cells; and (b) since DHT is associated with some unwanted physiological effects, these can be minimized by blocking DHT. Research seems to be backing this rationale up.

Here are the two most effective:

7) Saw Palmetto Extract--120 mg

Saw palmetto, Serenoa repens, is an extract from a tropical palm-like plant. It has achieved a reputation of being able to block the conversion of testosterone to DHT at certain target tissues. Although much of the evidence for this potential DHT inhibition is from anecdotal reports, when it comes to longevity in the health food industry, few substances have stood the test of time as has saw palmetto. Even many physicians recommend its use as a form of alternative medicine when DHT inhibition is sought. Saw palmetto has been proven to be effective in inhibiting DHT conversion. In a placebo-controlled, double-blind study, saw palmetto showed anti-estrogenic properties.

8) Beta-Sitosterol--250 mg

Plant sterols have been investigated as testosterone-facilitating agents and DHT inhibitors. You may recall gamma-oryzanol, a type of plant sterol, and its brief stint in the supplement industry. These sterols can inhibit cholesterol absorption in high dosages. At least one plant sterol, called beta-sitosterol, has been shown to have effects consistent with DHT inhibition.

For instance, in one study at 13 different centers, 130 mg of beta-sitosterol was given daily to 177 patients with benign prostatic hypertrophy for six months. Others received a placebo. Beta-sitosterol subjects had significantly better scores following supplementation in the international prostate symptom test. The investigators concluded that beta-sitosterol is an effective treatment option for BPH. TESTROGAIN® contains 250 beta-sitosterol, the exact same amount used in this research study.

SUPPLEMENT FACTS:

Serving Size: 2 Tablets
Servings Per Container: 45

Amount per
Serving % Daily
Value
Calcium 216 mg 22%
Vitamin B6 0.43 mg 22%
Phosphorus 167 mg 17%
Magnesium 18.5 mg 5%
Zinc (from Zinc picolinate) 50 mg 333%
ZMA™ Blend (Magnesium Aspartate, Zinc Aspartate, Zinc L-Monomethionine, Pyridoxine Hydrochloride) 100 mg *
Acetyl L-Carnitine Hydrochloride 500 mg *
Plant Sterol Concentrate 250 mg *
Novasoy® Soy Bean Extract (standardized for 40% isoflavones) 200 mg *
Tribulus Terrestris Fruit Extract (standardized for minimum 20% steroidal saponins) 150 mg *
Saw Palmetto Berry Extract 120 mg *
DHEA (dehydro-epi-androsterone) 50 mg *

Other Ingredients: Calcium Phosphate, Cellulose, Vegetable Stearic Acid, Croscarmellose Sodium, Silica, Magnesium Stearate, Dextrin, Dextrose, Lecithin, Sodium Citrate, Triacetin, Water. *Daily value not established.

PRODUCT DIRECTIONS:

As a dietary supplement, for best results, take 2 tablets in the morning.

Warnings: This product is not intended for use by those with a serious medical condition. Not for use by women or children. Do not use this product if you have prostate cancer or prostate problems. Persons suffering from or at risk for any disease should consult a health care professional before using this product. Keep out of reach of children.